Abietane diterpenoids from Salvia officinalis leaves as aryl hydrocarbon receptor ligands
نویسندگان
چکیده
One undescribed and six known abietane diterpenoids were isolated as ligands for aryl hydrocarbon receptor (AhR) from leaves of Salvia officinalis, a folk medicine in the Mediterranean Sea area. The structure diterpenoid named (+)-(10R)-11,14-dioxoabieta-8,12-diene-12,20-diol was assigned by 1D/2D NMR spectroscopic HR-ESI-MS data. AhR ligand activity evaluated AhR-dependent luciferase reporter system stably transfected HepG2 cells (HepG2-XRE). Each derived officinalis exhibited at 30 ?M.
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ژورنال
عنوان ژورنال: Phytochemistry Letters
سال: 2021
ISSN: ['1876-7486', '1874-3900']
DOI: https://doi.org/10.1016/j.phytol.2020.11.006